M et P Pharma AG
Platform for Drug Delivery by the Nasal Route

After a certain euphoria in the eighties of the last century the nasal application form for drug delivery to the systemic circulation and/or the brain has practically not been pursued further by the pharmaceutical industry.

This is not due to a lack of new drugs or ideas  to improve drug transport. Drug development for intranasal administration had rather been abandoned because the wrong or a non-convincing indication was selected. Many programs have been stopped for the reason  of problems with the applied formulation.

Over and above that, the effectiveness of drugs can very much depend on the time of day they are taken. Some examples:

1. Anti-hypertensives should preferably exert their action between 6 am and noon to reduce the early-morning rise in blood pressure. Sophisticated pharmaceutical controlled-delivery systems make it possible to take the medication in the evening and have the maximum effect in the early morning.
2. Statins should be dosed rather in the evening than in the morning since the liver manufactures more cholesterol in the evening than in the morning.
3. Virtually all endogenously produced substances follow a 24-h rhythm. The endocrine system provides many examples to this.

Thus endogenous rhythms have to be taken into account to optimize many types of treatment. The rapid uptake of the compounds through the nasal mucosa and the sustained release from the drug delivery system enable or facilitate dosing at the most appropriate time of the endogenous cycle.

M et P’s new approach for product development takes into account:

• the strong interrelation between the factors molecule, formulation and applicator
• chronobiological characteristics

Following the above said M et P Pharma AG’s proprietary technology provides a sophisticated way for drug delivery to the systemic circulation and to the brain.

The company has adopted a virtual business model and it does not anticipate being a marketing company. Thus, it seeks licensing agreements.

Literature

Schofl C, Prank K, Brabant G. (1995), Pulsatile hormone secretion for control of target organs, Wien Med Wochenschr 145 (17-18): 431-5

Ohdo S, Chronopharmacology Focused on Biological Clock (Review), Drug Metab. Pharmacokinet. 22(1):3-14 (2007)

Handbook of Experimental Pharmacology: Physiology and Pharmacology of Biological Rhythms: Bd. 125 (Handbook of Experimental Pharmacology), Redfern PH, Lemmer B, Springer, Berlin - 1997

Lemmer, B, Clinical Chronopharmacology: The Importance of Time in Drug Treatment, Ciba Foundation Symposium 183 - Circadian Clocks and their Adjustment: 235-253 (1995)

www.chronopharmacology.de/index.htm

www.touchbriefings.com/pdf/2514/Mattern_tech_final.pdf