Pipeline

M et P’s drug delivery system has been successful as evidenced by pre-clinical and clinical studies on the nasal administration of several drugs.

Nasobol® (MPP 10) treats male testosterone deficiency, counteracting typical physical and psychological symptoms of hypogonadism (from loss of muscle strengths to depression). Sustained release of testosterone into the blood yields restitution of the cyclical hormone concentrations of healthy young men.

Literature

Nasal application of testosterone (PDF)

www1.essm-congress.org/guest/AbstractView?ABSID=5765

Noseafix® (MPP 14) is a testosterone formulation for female sexual dysfunction. In phase-I trials acute CNS effects have been detected, indicating that an “on-demand” mode of administration may be preferable over daily application of testosterone.

Literature

www1.essm-congress.org/guest/AbstractView?ABSID=5777

van Wingen GA, Zylicz SA, Pieters S, Mattern C, Verkes RJ, Buitelaar JK, Fernández G, Testosterone Increases Amygdala Reactivity in Middle-Aged Women to a Young Adulthood Level, Neuropsychopharmacology. 2008 Jan 30

Topic B, Tavares MC, Tomaz C, Mattern C, Prolonged effects of intra-nasally administered testosterone on proceptive behavior in female capuchin monkeys (Cebus apella), Behavioural Brain Research, 2007, Vol. 179(1): 60-68

Tavares MC, Topic B, Abreu C, Waga I, Gomes U, Tomaz C, Mattern C, Effects of intra-nasally administered testosterone on sexual proceptive behavior in female capuchin monkeys (Cebus paella), Behavioural Brain Research, 2007, Vol. 179(1): 33-42. 

Dopamine has many functions in the brain. DopaMat (MPP 18) is a new delivery form for dopamine to access the brain treating malfunctions such as Parkinson’s disease. It will be the first product that brings genuine dopamine into the brain (as opposed to L-dopa which is currently used).

Literature

De Souza Silva MA, Topic B, Huston JP, Mattern C, Intranasal dopamine application increases dopaminergic activity in the neostriatum and nucleus accumbens and enhances motor activity in the open field, Synapse. 2007 Dec 14;62 (3):176-184

Progesterone belongs to the group of neurosteroids that are found at high concentrations in certain areas of the brain. The Company’s ProgestoMat (MPP 22) is supposed to deliver progesterone to the brain to treat PMS and depression, and to reduce neuronal death after traumatic brain injury.

Literature

Oettel M, Mukhopadhyay AK, Progesterone: the forgotten hormone in men?, Aging Male 2004 Sep; 7(3):236-57

Challis, JRG, Sparague C, Patrick JE (1983), Relation between diurnal changes in peripheral plasma progesterone, cortisol, and estriol in normal women at 30-31, 34-35, and 38-39 weeks of gestation, Gynec. obstet. Invest., 16, 33-44

Stein DG, Wright DW, Kellermann AL: Does Progesterone Have Neuroprotective Properties? Ann Emerg Med. 2008 Feb;51(2):164-72

Pregnenolone belongs to the group of neurosteroids that are found at high concentrations in certain areas of the brain. In a preclinical trial PregnenoMat (MPP 26) showed memory-enhancing effects at very low doses.

Literature

Flood JF, Morley JE, Roberts E (1995), Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive, Proc Natl Acad Sci USA 92: 10806–10810